Indeed, such fully s.c. implanted devices have already been developed and widely used in humans for passive immunization against Alzheimer’s disease by providing stable delivery of recombinant anti-amyloid-β antibodies66 and for intrathecal delivery of ciliary neurotrophic factor in amyotrophic lateral sclerosis patients67. The gene discussed is CNTF; the disease is early-onset autosomal dominant Alzheimer disease.