For example, one of the top phenotype combinations (by odds ratio) was the combination of joint disorders + osteoarthrosis + pleurisy or pleural effusion + HFpEF, which had a prevalence of 18.1% in wild-type ATTR-CM vs. 3.6% in non-amyloid HF (odds ratio 5.8 [95% CI 4.0–8.5], p = 1.51 × 10−28). The gene discussed is TTR; the disease is pleurisy.