Daily intraperitoneal (i.p.)administration of the sGC inhibitor ODQ (20 mg/kg/day) to 14-week-old MFS mice (Fig. 7a) markedly decreased plasma cGMP (Fig. 7b), inhibited Prkg activity determined by pVASP-S239 aortic staining (Fig. 7c, d), and completely reversed AsAo and AbAo dilation after 7 days without inducing arterial hypertension (Fig. 7e, f). Here, SGCB is linked to Hypertension.