Notably, other cancer types, such as esophageal and ovarian cancers, in which aberrantly activated Notch1 signaling plays important roles, also have distinct high proportions of RFC4 gene amplification, and high RFC4 levels significantly correlates with poor prognosis of patients with these cancers, indicating that the oncogenic effects of RFC4 are not limited to NSCLC. Here, NOTCH1 is linked to cancer.