RFC4 and non-small cell lung carcinoma: Furthermore, NSCLC patients with RFC4 amplification or high RFC4 DNA copy numbers in their lung tumors showed shorter overall or metastasis-free survival than those without RFC4 amplification or with low RFC4 DNA copy numbers (Fig. 7h, i), suggesting a role of RFC4 gene amplification in the progression and possibly also the prognosis of NSCLC.