RFC4 and lung carcinoma: Based on our findings of a robust capacity role of RFC4 in inducing stemness and metastasis properties in NSCLC, as well as a positive correlation of RFC4 with the stemness- and metastasis-promoting signature, as shown by the analysis of a large number of RNA-seq profiles of TCGA lung cancer datasets, it is highly likely that RFC4 represents a functional Notch target gene.