RFC4 and lung carcinoma: Consistently, silencing RFC4 significantly suppressed the ability of highly metastatic murine lung cancer cells to form lung metastases when injected intravenously or to develop subcutaneous tumors when injected with various cell numbers ranging from 5 × 103 to 5 × 105 in C57BL/6N mice (Fig. 3f, g and Supplementary Fig. 3l).