HES1 and lung cancer: It is also important to note that, based on the RNA-seq data of tumor tissues of 971 NSCLC patients in the TCGA lung cancer datasets, the expression levels of RFC4 positively correlated with not only cell proliferation markers but also with overactivation of Notch1 signaling, especially with the expression levels of its several canonical downstream genes, such as HES1, HEY1, HEY2, and NRARP (Fig. 4f, g and Supplementary Fig. 6i).