mRBC-OVA-4-1BBL-IL-12 and mRBC-OVA-4-1BBL-IL-15 induced significant expansion of circulating OT-1 cells compared with mRBC-CTRL (unmodified mouse RBCs), mRBC-OVA-4-1BBL, or mRBC-OVA-4-1BBL-IL-7 in EG7.OVA tumor-bearing mice that were administered two doses of mRBC-aAPC (Fig. 1b, c). This evidence concerns the gene IL15 and neoplasm.