IFNG and neoplasm: Consistent with this, TCRβ sequencing demonstrated that OT-1 was the most abundant T-cell clone in both blood and tumors (Fig. 1m), and treatment with mRBC-OVA-4-1BBL-IL-12 increased the percentage of polyfunctional (granzyme B+IFNγ+) tumor-infiltrating OT-1 cells (Fig. 1n).