IFNAR2 and infectious otitis media: Wild type (WT) and single type I or type III IFN receptor (IFNR)-deficient (Ifnar1−/− or Ifnlr1−/−) or double IFNR-deficient (Ifnar1−/−Ifnlr1−/−) mice were administered a single intraperitoneal (IP) injection of the carcinogen AOM followed by three cycles of 1.5% DSS in the drinking water for 7 days followed by regular water for 14 days (Supplementary Fig. 1a).