IFNB1 and colitis: On the one hand, Ifnar1−/− mice are more sensitive to DSS-induced colitis, and administration of type I IFNs is protective90,91, but recovery from DSS-induced injury was accelerated in IFNAR-deficient mice21, and intestinal delivery of IFN-β by Lactobacillis exacerbated the DSS-induced symptoms92.