As observed in the AOM/DSS model, 88% of Ifnar1−/−Ifnlr1−/− mice again did not survive DSS exposure, with only 12% of these animals surviving to the experimental endpoint, while 82% of WT mice and 100% of singly IFNR-deficient mice survived after an initial weight loss (Fig. 1a). This evidence concerns the gene IFNAR2 and infectious otitis media.