Cardiac amyloidosis is subclassified based on the specific protein involved, with the major subtypes being transthyretin amyloidosis (ATTR cardiac amyloidosis), caused by misfolding of the transthyretin protein, and light chain amyloidosis (AL cardiac amyloidosis), caused by accumulation of immunoglobulin light chains1. The gene discussed is TNFSF14; the disease is cardiac amyloidosis.