Indeed, dual therapeutic vaccination demonstrated a profound reduction in key features of asthma, including a ~2-fold reduction of total and HDM-specific IgE levels (Fig. 3d, e), of AHR to inhaled methacholine (Fig. 3f, g), of airway eosinophilia (Fig. 3h), and a ~6-fold reduction in mucus production (Fig. 3i, j). Here, IGHE is linked to asthma.