IL4 and asthma: Since dual IL-4-K/IL-13-K prophylactic vaccination prevented or strongly reduced all key features of HDM-induced asthma in mice, whereas single IL-4-K or IL-13-K vaccination affected only a subset of these features (Figs. 1 and 2), we assessed the efficacy of therapeutic vaccination only using dual IL-4-K/IL-13-K vaccination on mice with established asthma (Fig. 3a and Supplementary Fig. 14).