We developed mouse IL-4 and IL-13 kinoids (IL-4-K and IL-13-K), by coupling these cytokines with diphtheria “cross-reactive material 197” (CRM197, a nontoxic mutant of diphtheria toxin used as a carrier protein in a number of approved conjugate vaccines16) using a thiol-maleimide conjugation (Supplementary Figs. 1 and 2). Here, IL4 is linked to diphtheria.