CRMA and neoplasm: IFNγ produced by converted Treg cells and CD8 T cells after αPD1 + αGITR combination therapy may also have an additional effect of driving the reprogramming of subsequent waves of tumor Treg cells, as suggested by observations made in the context of Helios−/−, NRP1−/−, and/or CARMA−/− Treg cells40,58,68.