Furthermore, blockade of IFNγ with a neutralizing antibody abrogated the ability of T cells to kill tumor cells (Supplementary Fig. 15, Supplementary Fig. 16), suggesting the role of T cell-derived IFNγ in the regulation of MHC molecules and therapeutic responses to αGITR + αPD1 potentially through direct recognition of antigens. This evidence concerns the gene HLA-C and neoplasm.