CD4 and neoplasm: Indeed, the tumors induced by the re-expression glycosylated B7H3 cells not only had decreased total CD4+ T, CD8+ T, and NK populations (Fig. 4g), but also had fewer activated cytotoxic CD8 T cells in their tumor-infiltrating lymphocytes (TILs) populations (IFNγ+CD8+ T and granzyme B+CD8+ T) than those tumors with re-expression of non-glycosylated B7H3 (Fig. 4g).