In this study, we showed that 2F-Fuc not only repressed core fucosylation of B7H3 expression, but also obviously restored the tumor cells’ susceptibility to cytotoxic T-cell-mediated death mainly in cells with re-expression of glycosylated B7H3, but not in cells with re-expression of non-glycosylated B7H3. Here, CD276 is linked to neoplasm.