In this context, it is interesting to note that reduced expression of INPP5A and changes in the synthesis, and/or surface expression of glycosphingolipids and cholesterol have been associated with cancer and metastasis16,20, processes regulated by the exo-endocytosis of cell signaling and adhesion receptors such as integrins, and with regulated cell death by apoptosis73. Here, INPP5A is linked to cancer.