Analysis of the Bax, Bcl-2, E-cad, N-cad, and Snail expressions in tumor tissues by IHC staining showed that CircRNA_2646 overexpression lowered Bax and E-cad levels, but enhanced the Bcl-2, N-cad, and Snail levels in ESCC tissues of mice (Fig. 6D). The gene discussed is CDH2; the disease is esophageal squamous cell carcinoma.