While several of these factors blocked virus infection at early stages of the virus life cycle prior to morphogenesis, one of these factors, the endosomal sorting required for transport complex III (ESCRT-III) component CHMP4C, was shown to localize to and be required for the integrity of the recycling endocytic network needed for the envelopment of HSV1, which is suggestive of a role for this protein in the scission of these endocytic membranes. The gene discussed is CHMP4C; the disease is viral infectious disease.