Importantly, urinary hippurate levels showed significant negative associations with markers for metabolic impairments such as body mass index (BMI), body weight, the homeostasis model assessment of insulin resistance (HOMA-IR), interleukin-6 (IL-6), insulin and C-peptide (partial Spearman’s correlations, q<0.1, online supplemental figure 2C). The gene discussed is IL6; the disease is Insulin resistance.