The LINC00649 knockdown vectors, miR-16-5p inhibitor and YAP1 overexpression vectors were delivered into the GC cells, which were subsequently divided into four groups, including Control, KD-LINC00649 group, KD-LINC00649 + KD-miR-16-5p group, and KD-LINC00649 + OE-YAP1 group. The gene discussed is LINC00649; the disease is gastric cancer.