GM-CSF has a crucial role in monocyte generation and macrophage activation in myocardial infarction and inflammatory diseases.28,29 IFNγ preferentially induces macrophage formation at the expense of DCs in vitro,30 promotes monopoiesis,31 and remodels the blood monocyte compartment in gut inflammation by expanding MHCII+Sca1+Ly6Chi monocytes. The gene discussed is IFNG; the disease is myocardial infarction.