Mouse mutants with conditional deletion of the Angiopoietin 1 and 2 (Angpt1/2) ligands that bind to the TIE receptors develop ocular enlargement and optic neuropathy, in addition to complete absence of Schlemm's canal, a modified lymphatic that drains aqueous humor from the eye [31]. This evidence concerns the gene ANGPT1 and Optic neuropathy.