CTD+ CM-1 cases had a significantly higher percentage of rare, functional variants in COL7A1 and a significantly lower percentage of rare, functional variants in COL3A1. These associations remained significant when CM-1 patients who had a formal EDS diagnosis were excluded from the analysis (COL7A1 p = 0.0025; COL3A1 p = 0.0385; Table 3). The gene discussed is COL3A1; the disease is Ehlers-Danlos syndrome.