CDH17 and viral infectious disease: In line with the notion that alterations in junction protein integrity play a role in the acquired sensitivity to SARS-CoV-2, GO analysis of the RNA-Seq upregulated genes in lungs of LDR mice at the time of viral infection demonstrated the enrichment of pathways involved in protein binding, including enrichment of gene clusters involved in the cadherin binding pathway (molecular function in Supplemental Table 2).