IL5 and vasculitis: To test the role of ILC2s in vasculitis, we crossed IL5Tg mice to Il5Red5CreROSA-DTA ILC2-deficient R5/R5 deleter (ILC2del) mice, in which mature ILC2s — which constitutively produce IL-5 — are deleted via Cre-inducible expression of diphtheria toxin alpha from the endogenous IL-5 promoter (10).