Thus, by searching the PubMed database with the keywords: “Pharmacogenetics, Type 2 diabetes”, “SGLT-2 inhibitors pharmacogenetics”, “DPP-IV inhibitors pharmacogenetics”, “GLP-1R agonists pharmacogenetics”, and “Type 2 diabetes personalized medicine”, the aim of this review was to summarize the results of the studies published so far on the potential use of pharmacogenetics in the treatment with newer antidiabetic drugs. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.