Finally, since it is known from in vitro data that gliptins show protective effects against hepatic steatosis [74], Kan et al. attempted to link patatin-like phospholipase 3 gene (PNPLA3) rs738409 C>G genotype with the efficacy of alogliptin in NAFLD patients with T2D [75]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.