Compared with NT, the expression of all hub genes in TT was significantly upregulated, of which eight hub genes (CENPE, SPDL1, HMMR, RACGAP1, TRIP13, CKAP2, CKAP5, and ITGB3BP) were identified as prognostic hub genes and independent prognostic factors for HCC. Here, ITGB3BP is linked to hepatocellular carcinoma.