CENPE, SPDL1, Hyaluronan-mediated motility receptor (HMMR), Rac GTPase activating protein 1 (RACGAP1), Thyroid hormone receptor interactor 13 (TRIP13), cytoskeleton-associated protein 2 (CKAP2), CKAP5, and Integrin subunit beta 3 binding protein (ITGB3BP) were identified as prognostic biomarkers and therapeutic targets for HCC. Here, SPDL1 is linked to hepatocellular carcinoma.