Similarly, the expression level of 9 hub genes (CENPE, CKAP2, CKAP5, HMMR, ITGB3BP, RACGAP1, SMC2, SPDL1, and TRIP13) was associated with disease-free survival (DFS) of HCC patients (Figure 4). This evidence concerns the gene SMC2 and hepatocellular carcinoma.