Next, we found that in LR-HCC cells, MT1JP silencing resulted in alterations in cell viability (Fig. 3b), leading to a 2.2-fold upregulation of the apoptotic rate (Fig. 3c-d) and an induction of the apoptosis signaling pathway, after Lenvatinib exposure (Fig. 3e). This evidence concerns the gene MT1JP and hepatocellular carcinoma.