In CKD-5D, significantly greater risk of any type of incident fracture has been associated with PTH levels either <150 pg/mL (hazard ratio (HR) = 3.47, P < 0.01] or >300 pg/mL (HR = 5.88, P < 0.0001) compared with 150–300 pg/mL [48]. Here, PTH is linked to chronic kidney disease.