The imbalance of classical ACE 1/Angiotensin II (Ang II) /AT1 receptor axis andcounter-regulatory ACE 2/Ang 1-7/MAS receptor axis was studied by Belisario et al.(2018) highlighting that ACE 2 and Ang 1-7 were reduced in pediatric SCD withincrease of ACE 1 and Ang II, inducing kidney damage9. Here, ANGPT1 is linked to Schnyder corneal dystrophy.