In addition, we demonstrated that Beclin 1 knockdown reduced the myocardial LC3‐II/LC3‐I ratio and P62 expression, while Beclin 1 overexpression blocked TAC preconditioning‐mediated autophagosome processing, as evidenced by the increased LC3‐II/LC3‐I ratio and P62 expression. Here, BECN1 is linked to persistent truncus arteriosus.