UNC80 and neurodevelopmental disorder: Interest in the UNC79-UNC80-NALCN pathway has also risen, due to its essential role in the maintenance of respiration (Lu et al., 2007), the regulation of circadian rhythms (Lear et al., 2013; Flourakis et al., 2015), and because mutations of UNC80 and NALCN cause neurodevelopmental disorders, characterized by development delay and hypotonia (Al-Sayed et al., 2013; Perez et al., 2016).