Thus, in the light of GSH predictions, we may expect that in the case of conventional metaphors (figurative but salient content) impairment will be related especially to the diminished activity of the LH regions (e.g. IFG, Precuneus, IPL) and we may expect reversed directionality of information flow compared to the controls, as a reflection of reversed language lateralization in schizophrenia (Mitchell and Crow 2005). This evidence concerns the gene PLOD1 and schizophrenia.