RPS6KA3 and glioblastoma: In a related study investigating the link between RSKs and metastasis in Glioblastoma (GBM), Shi et al. [73] showed that, downstream of EGF signaling, RSK2 phosphorylates Leukemia-Associated Rho Guanine exchange factor (LARG) on S1288, which in turn binds and activates RhoA GTPase, resulting in increased cellular migration and invasion.