PRDM1 and diffuse large B-cell lymphoma: However, investigation of the activated B cell-like diffuse large B-cell lymphoma (DLBCL) demonstrated the presence of variable percentages of PRDM1-positive tumor cells in approximately half of the DLBCL cases and showed that patients with higher PRDM1 expression are significantly correlated with shorter failure-free survival41, which raises the possibility that higher PRDM1 expression is positively linked to tumor progression.