A comparison of imaging data of real and synthetic IDH-mutant glioblastomas showed no differences in tumor location (x2 test, P = 0.55), degree of necrosis (P = 0.35), and tissue (P = 0.39) and margins (P = 0.10) surrounding regions of high signal intensity The patch enhancing pattern was observed more frequently in the synthetic than in the real imaging data (P = 0.01). Here, IDH2 is linked to glioblastoma.