Second, although this study included qualitative imaging features from structural MRI with high reproducibility in several studies8,9,38, physiologic imaging biomarkers can be helpful in differentiating IDH-mutant glioblastoma, demonstrating less aggressive imaging features with higher ADC values and less hyperperfusion on CBV than IDH-wild type glioblastoma38–40. Here, IDH2 is linked to glioblastoma.