PF4 and Hepatic fibrosis: Furthermore, data about the relationship between modifications of liver fibrosis, both in HCV-monoinfected and HIV/HCV coinfected patients, and the serum concentrations of serum markers of fibrosis (CXCL4 or TGF-β1) or regeneration/proliferation (HGF), are also scarce and controversial9,11,12, even though these parameters could be markers of fibrosis evolution.