Furthermore, in Apc deficient adenomas that had developed in heterozygous Apc mutant mice, CtBP2 expression was high at the basolateral site of the adenomas, with hotspots in central and luminal areas (Fig. 5B), corresponding with the described distribution of Lgr5-positive tumor stem cells in early-stage adenomas36. Here, CTBP2 is linked to neoplasm.