Although inflammasomes are associated with several types of diseases, there are few studies that demonstrate the relationship between the SNVs involving IL1B (Interleukin 1 beta), IL18 (Interleukin 18), NLRP1 (NLR family pyrin domain containing 1), NLRP3 (NLR family pyrin domain containing 3) and P2RX7 (Purinergic receptor P2X7) genes and their susceptibility or influence on the prognosis of ALL patients. This evidence concerns the gene IL1B and acute lymphoblastic leukemia.