Studies describe the high expression of P2RX7 in samples from ALL patients, especially those who relapse, as well as an association with dysregulation of the HSPCs’ normal functioning, since it affects the ability of colony formation in vitro, which impairs the clonal expansion process observed in the HSPCs. However, the role of this mechanism in the development of ALL is still unknown 42. The gene discussed is P2RX7; the disease is acute lymphoblastic leukemia.