AKT1 and plasma cell myeloma: Another of the top hits in this analysis was “phosphatidylinositol 3-kinase complex”, which is part of the ”phosphatidylinositol 3-kinase/AKT (PI3K/AKT)” pathway, and addition of the PI3K/AKT inhibitor (BKM120) to the culture of the BTZ resistant myeloma cells increased the apoptotic effect and eliminated resistance to BTZ45.