Importantly, none of the ALS-associated interactors involved in transcriptional or post-transcriptional regulation were identified among TDP-43 interactors in any of the cancer lines (Supplementary Data 5), suggesting that in a nonneuronal context, TDP-43 may function through a different molecular mechanism involving a discrete set of cell-type-specific interactors. Here, TARDBP is linked to amyotrophic lateral sclerosis.