TARDBP and amyotrophic lateral sclerosis: Interestingly, a large portion of TDP-43 interactors in GPiNs (including two out of six ALS-associated interactors, FUS and HNRNPA2B1) are involved in RNA metabolism, suggesting that the role of TDP-43 in human neurons is mostly related to transcriptional and post-transcriptional regulation, as highlighted using Genoppi’s gene set annotation feature (Fig. 2i).