In support of ALT activation in our cell models, we detected ALT-associated hallmarks in H3.3G34RAPT-tKO cells including telomeric C-circle DNA (Fig. 1d)29, sister chromatin exchange (Fig. 1e, Supplementary Fig. S2c; examples of TSCE are shown), and large ALT-associated promyelocytic leukaemia (PML) bodies (APBs) (Fig. 1f, g). The gene discussed is PML; the disease is leukemia.