To further elucidate sources of E/I disruption in the parietal cortex in AD, we used publicly available in situ hybridization image data from the ADTBI study27, to quantify the number of glutamatergic neurons that expressed mRNA for the excitatory vesicular glutamate transporter 1 (vGluT1) and GABAergic neurons that expressed mRNA for GABA transporter 1 (GAT1), in a well-defined area of the cortex. This evidence concerns the gene SLC6A1 and Alzheimer disease.