While the DS cases exhibited marked reductions in PSD-95 and GPHN immunofluorescence, similar to the AD group, the anatomical and electrophysiological E/I ratios for the DS group were not significantly different from controls, indicating that either homeostatic mechanisms are still functional or disturbances to excitatory and inhibitory synapses are comparable. The gene discussed is DLG4; the disease is Dravet syndrome.