According to the average value of AGAP2-AS1, miR-296, and NOTCH2 expression, the lung cancer patients were separated into the high expression and low expression groups, and the relation between AGAP2-AS1, miR-296, and NOTCH2 expression and clinicopathological characteristics and prognosis of lung cancer patients was analyzed. This evidence concerns the gene NOTCH2 and lung carcinoma.