IL17A and skin basal cell carcinoma: Up-regulated KEGG pathways in advanced BCC included pathways that were also found to be up-regulated when comparing all BCC tumors with normal skin samples: protein digestion and absorption (P = 1.3 × 10−08), extracellular matrix–receptor interactions (P = 1.4 × 10−08), IL-17 signalling (P = 0.0039), and cytokine–cytokine receptor interactions (P = 0.011) (Figs 5B and S4 and Table S12).