AFP and cancer: To further confirm the effect of the CNV risk score of plasma cfDNA at baseline on the OS of patients with hepatobiliary cancer who received combination therapy, multiple Cox regression was used to assess the effect of multiple factors, including cancer type, PD-L1 expression, ECOG score, Child-Pugh score, alpha-fetoprotein (AFP), TBS, macrovascular invasion, etiology, TNM stage and CNV risk score, on OS.