WEE1 and bronchopulmonary dysplasia: Similar to other early-onset severe diseases, including CHD and bronchopulmonary dysplasia, the genes identified fit a general pattern for developmental disorders—genes intolerant to loss of function variants (pLI > 0.5 for 40% of the genes) and with known functions as transcription factors, RNA-binding proteins, protein kinases, and chromatin modification.