Specific inhibition of the protein encoded by PTPN11 (SHP2) [97], and induction of mir-204 which negatively targets SHP2 [98], improved right ventricular function in the monocrotaline rat model of PAH, suggesting a more general role of PTPN11 in PAH. The gene discussed is PTPN11; the disease is pulmonary arterial hypertension.