We next screened the entire combined cohort, including participants of non-European ancestry, for rare deleterious missense variants in FBLN2 and PDGFD. In total, seven cases carry FBLN2 variants (6 IPAH, 1 APAH) and ten cases carry PDGFD variants (9 IPAH, 1 PAH associated with diet and toxins) (Table 2). Here, FBLN2 is linked to pulmonary arterial hypertension.