We describe a highly unusual presentation of sarcoidosis, with a cough productive of glazy mucoid sputum, accompanied by fever and transient arthralgias, radiographically stage 1, without evidence of complicating infection, and followed by complete resolution of symptoms with TNF-alpha inhibitor (infliximab) therapy, a response that persisted for over 12 years, and a relapse of symptoms following each of two different attempts to taper her infliximab therapy. The gene discussed is TNF; the disease is sarcoidosis.