AFP and hepatocellular carcinoma: The positive rates of combined detection of serum AFP, AFP-L3, and CTCs were also compared, and it was found that in the HCC group, the positive detection rate of serum AFP paired with AFP-L3, serum AFP paired with CTCs, serum AFP-L3 paired with CTCs, serum AFP combined with AFP-L3 and CTCs increased to 88.1 %, 90.9 %, 93.0 and 97.2 %, respectively, as shown in Table 3.