We recommend assessing Crohn’s disease or ulcerative colitis disease activity in the urgent clinical situation by performing the following laboratory tests: a full blood count, including hemoglobin, leukocyte count, and platelet count; serum C-reactive protein level, erythrocyte sedimentation rate; serum electrolytes; liver enzymes level; serum albumin; renal function; and fecal calprotectin level, when it is possible. This evidence concerns the gene CRP and Crohn disease.