Apoptosis results were displayed in Fig. 4f, g, compared with the control group, the cell apoptotic rates was increased significantly after sh-FRLnc1 transfected (Fig. 4f); in addition, the qRT-PCR results showed that, after exosome treatment, decreased expression of Bcl-2 and increased expression of Bax were observed(Fig. 4g); in Fig. 4j, Western blot results showed that down-regulated expression of Bcl-2 was found in HGC-27 cells treated by sh-FRLnc1 transfected, revealing that the treatment of sh-FRLnc1 transfected could promote the apoptosis of GC cells. This evidence concerns the gene BCL2 and gastric cancer.