In the subgroup of 106 patients with NAFLD whose ALT levels returned to normal after 12 months of treatment, the multivariate models showed that weight loss (OR = 1.43, 95% CI: 1.10–1.86, P = 0.01) and a decrease in HOMA-IR to a normal level (OR = 5.01, 95% CI 1.09–23.08, P = 0.04) remained independent factors associated with GGT normalization (Fig. 3b, Additional file 1: Table S6). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.