Recently, we extended the analysis about the functional role of NTAL in APL, showing that reduced NTAL levels were associated with increased all-trans retinoic acid (ATRA)–induced cell differentiation, reactive oxygen species generation, Ras activation, and Akt/mammalian target of rapamycin (mTOR) pathway inhibition. This evidence concerns the gene LAT2 and acute promyelocytic leukemia.