Subsequently, GSEA associated NTAL interactors of high AML patients with the terms “Oxidative phosphorylation metabolism,” “L-GMP signature” and “Up-regulated genes in AML patients with NPM1 mutant,” whereas interactors of the low AML patients were associated with “HSC-like signature” and “17 Leukemic stem cell genes” (Fig. 6C). Here, NPM1 is linked to acute myeloid leukemia.