Possible mechanisms underlying this sex-based difference in the prevalence of sarcopenia include 1) SMM loss tends to occur gradually with age in men, whereas this decline in SMM with age is less apparent among women [35] and 2) insulin-like growth factor-1 and testosterone levels decrease significantly with age among men, leading to the rapid loss of strength and SMM and an increased risk of sarcopenia [36]. This evidence concerns the gene IGF1 and sarcopenia.