In terms of possible therapeutic targets, our model suggests that overactivating VMAT2 expression twice, a strategy proposed as a therapeutic intervention to re-establish the physiological levels of DA in patients with Parkinson’s diseased or bipolar disorder [32], does not seem to be an efficient approach in comparison to the untreated system, at least with regard to higher levels of glucocorticoids. This evidence concerns the gene SLC18A2 and bipolar disorder.